Anti-RBM17 antibody (1-240) (STJ26216)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RBM17 (1-240) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RBM17 |
| Gene ID | 84991 |
| Uniprot ID | SPF45_HUMAN |
| Immunogen Region | 1-240 |
| Immunogen Sequence | MSLYDDLGVETSDSKTEGWS KNFKLLQSQLQVKKAALTQA KSQRTKQSTVLAPVIDLKRG GSSDDRQIVDTPPHVAAGLK DPVPSGFSAGEVLIPLADEY DPMFPNDYEKVVKRQREERQ RQRELERQKEIEEREKRRKD RHEASGFARRPDPDSDEDED YERERRKRSMGGAAIAPPTS LVEKDKELPRDFPYEEDSRP RSQSSKAAIPPPVYEEQDRP RSPTGPSNSFLANMGGTVA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human RBM17 (NP_116294.1). |
Additional Info
| Function | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. |
| Protein Name | Splicing Factor 4545 Kda-Splicing FactorRna-Binding Motif Protein 17 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Splicing Factor 45 antibodyAnti-45 Kda-Splicing Factor antibodyAnti-Rna-Binding Motif Protein 17 antibodyAnti-RBM17 antibodyAnti-SPF45 antibody |
Information sourced from Uniprot.org