| Host: |
Guinea Pig |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse/Rat/Marmoset |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Guinea Pig polyclonal antibody anti-Rhodopsin is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Shipped as lyophilised. Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. |
| Purification: |
Ammonium sulphate precipitation |
| Dilution Range: |
A dilution of 1:2000 is recommended for IHC-P and WB. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Rho |
| Gene ID: |
24717 |
| Uniprot ID: |
OPSD_RAT |
| Specificity: |
Specific for Rhodopsin. |
| Immunogen: |
A synthetic peptide from human Rhodopsin conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse and rat. |
| Function | Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. |
| Protein Name | Rhodopsin |
| Database Links | Reactome: R-RNO-2453902Reactome: -RNO-2485179Reactome: -RNO-2514859Reactome: -RNO-418594Reactome: -RNO-419771Reactome: -RNO-5620916 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell ProjectionCiliumPhotoreceptor Outer SegmentSynthesized In The Inner Segment (Is) Of Rod Photoreceptor Cells Before Vectorial Transport To Disk Membranes In The Rod Outer Segment (Os) Photosensory Cilia |
| Alternative Antibody Names | Anti-Rhodopsin antibodyAnti-Rho antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
