Anti-RNASE6 antibody (1-150) (STJ117507)

Name: Anti-RNASE6 antibody (1-150) (STJ117507)
SKU: STJ117507
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ117507

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Short Description	Rabbit polyclonal RNASE6 (1-150) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:200-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	RNASE6
Gene ID	6039
Uniprot ID	RNAS6_HUMAN
Immunogen Region	1-150
Immunogen Sequence	MVLCFPLLLLLLVLWGPVCP LHAWPKRLTKAHWFEIQHIQ PSPLQCNRAMSGINNYTQHC KHQNTFLHDSFQNVAAVCDL LSIVCKNRRHNCHQSSKPVN MTDCRLTSGKYPQCRYSAAA QYKFFIVACDPPQKSDPPYK LVPVHLDSIL
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human RNASE6 (NP_005606.1).

Tissue Specificity	Highly expressed in spleen (at protein level). Has little or no expression in healthy kidneys (at protein level). Detected in interstitial leukocytes in infected kidneys (at protein level). Expressed in ureter where it localizes to urothelial and submucosal leukocytes (at protein level). Strong expression in lung and thymus, and lower expression in heart, placenta, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils.
Function	Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity.
Protein Name	Ribonuclease K6 Rnase K6
Database Links	Reactome: R-HSA-6803157
Cellular Localisation	Secreted Lysosome Cytoplasmic Granule
Alternative Antibody Names	Anti-Ribonuclease K6 antibody Anti-Rnase K6 antibody Anti-RNASE6 antibody Anti-RNS6 antibody

Information sourced from Uniprot.org