Anti-RNH1 antibody (202-461) (STJ25374)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RNH1 (202-461) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNH1 |
| Gene ID | 6050 |
| Uniprot ID | RINI_HUMAN |
| Immunogen Region | 202-461 |
| Immunogen Sequence | EALKLESCGVTSDNCRDLCG IVASKASLRELALGSNKLGD VGMAELCPGLLHPSSRLRTL WIWECGITAKGCGDLCRVLR AKESLKELSLAGNELGDEGA RLLCETLLEPGCQLESLWVK SCSFTAACCSHFSSVLAQNR FLLELQISNNRLEDAGVREL CQGLGQPGSVLRVLWLADCD VSDSSCSSLAATLLANHSLR ELDLSNNCLGDAGILQLVES VRQPGCLLEQLVLYDIYWS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 202-461 of human RNH1 (NP_002930.2). |
Additional Info
| Post Translational Modifications | The N-terminus is blocked. At least 30 of the 32 cysteine residues are in the reduced form. |
| Function | Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG). May play a role in redox homeostasis. Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress. Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus. |
| Protein Name | Ribonuclease InhibitorPlacental Ribonuclease InhibitorPlacental Rnase InhibitorRibonuclease/Angiogenin Inhibitor 1Rai |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusLocalizes In The Cytoplasm In Absence Of StressTranslocates To The Nucleus In Response To Stress |
| Alternative Antibody Names | Anti-Ribonuclease Inhibitor antibodyAnti-Placental Ribonuclease Inhibitor antibodyAnti-Placental Rnase Inhibitor antibodyAnti-Ribonuclease/Angiogenin Inhibitor 1 antibodyAnti-Rai antibodyAnti-RNH1 antibodyAnti-PRI antibodyAnti-RNH antibody |
Information sourced from Uniprot.org