Anti-SARM1 antibody (Full Length) (STJA0004904)

SKU:
STJA0004904-100

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Host: Rabbit
Applications: WB/ICC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SARM1 (Full Length) is suitable for use in Western Blot and Immunocytochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Purification: Antigen Affinity Purified from Pooled Serum
Dilution Range: WB 1:1000
IHC
ICC 1:50
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SARM1
Gene ID: 23098
Uniprot ID: SARM1_HUMAN
Immunogen Region: Full Length
Specificity: Specific for endogenous levels of the ~79 kDa SARM1 protein.
Immunogen: Full length recombinant human SARM1 protein
Immunogen Sequence: Full-Length
Tissue Specificity Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta.
Post Translational Modifications Phosphorylation at Ser-548 by JNK kinases (MAPK8, MAPK9 and /or MAPK10) enhance the NAD(+) hydrolase (NADase) activity. Phosphorylation at Ser-548 and subsequent activation takes place in response to oxidative stress conditions and inhibits mitochondrial respiration.
Function NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide.NAD(+) cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
Protein Name Nad(+ Hydrolase Sarm1
Nadase Sarm1
Hsarm1
Nadp(+ Hydrolase Sarm1
Sterile Alpha And Armadillo Repeat Protein
Sterile Alpha And Tir Motif-Containing Protein 1
Sterile Alpha Motif Domain-Containing Protein 2
Myd88-5
Sam Domain-Containing Protein 2
Tir-1 Homolog
Hstir
Database Links Reactome: R-HSA-166166 Q6SZW1-1
Reactome: R-HSA-168164 Q6SZW1-1
Reactome: R-HSA-936964 Q6SZW1-1
Reactome: R-HSA-937041 Q6SZW1-1
Reactome: R-HSA-937072 Q6SZW1-1
Cellular Localisation Cytoplasm
Cell Projection
Axon
Dendrite
Synapse
Mitochondrion
Associated With Microtubules
Alternative Antibody Names Anti-Nad(+ Hydrolase Sarm1 antibody
Anti-Nadase Sarm1 antibody
Anti-Hsarm1 antibody
Anti-Nadp(+ Hydrolase Sarm1 antibody
Anti-Sterile Alpha And Armadillo Repeat Protein antibody
Anti-Sterile Alpha And Tir Motif-Containing Protein 1 antibody
Anti-Sterile Alpha Motif Domain-Containing Protein 2 antibody
Anti-Myd88-5 antibody
Anti-Sam Domain-Containing Protein 2 antibody
Anti-Tir-1 Homolog antibody
Anti-Hstir antibody
Anti-SARM1 antibody
Anti-KIAA0524 antibody
Anti-SAMD2 antibody
Anti-SARM antibody

Information sourced from Uniprot.org

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