| Tissue Specificity | Highly expressed in lung and trachea. Detected throughout the airway epithelium in lung, with slightly higher expression in large airways. Found in lung submucosal gland acinus where it localizes to serous-like cells. Probably expressed in club cells of the bronchioles. Not detected in other tissues tested. |
| Function | Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). |
| Protein Name | Secretoglobin Family 3a Member 2Pneumo Secretory Protein 1Pnsp-1Uteroglobin-Related Protein 1 |
| Database Links | Reactome: R-HSA-3000480 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Secretoglobin Family 3a Member 2 antibodyAnti-Pneumo Secretory Protein 1 antibodyAnti-Pnsp-1 antibodyAnti-Uteroglobin-Related Protein 1 antibodyAnti-SCGB3A2 antibodyAnti-PNSP1 antibodyAnti-UGRP1 antibodyAnti-UNQ566 antibodyAnti-PRO1128 antibody |
Information sourced from Uniprot.org
