| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Equilibrative nucleoside transporter 3 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC29A3 |
| Gene ID: | 55315 |
| Uniprot ID: | S29A3_HUMAN |
| Specificity: | This antibody detects endogenous levels of human S29A3 |
| Immunogen: | Synthesized peptide derived from human S29A3 |
| Function | Uniporter that mediates the facilitative transport of nucleoside across lysosomal and mitochondrial membranes. Functions as a non-electrogenic Na(+)-independent transporter. Substrate transport is pH-dependent and enhanced under acidic condition, probably reflecting the location of the transporter in acidic intracellular compartments. Proton is not a cotransporting ion but most likely change the ionization state of the transporter which dictates transport-permissible/impermissible conformation for nucleoside translocation. May direct the nucleoside transport from lysosomes to cytosol or cytosol to mitochondria to facilitate the fundamental function of salvage synthesis of nucleic acids. Involved in the transport of nucleosides (adenosine, guanosine, uridine, thymidine, cytidine and inosine) and deoxynucleosides (deoxyadenosine, deoxycytidine). Also mediates transport of purine nucleobases (adenine, guanine) and pyrimidine nucleobases (uracil). Also able to transport monoamine neurotransmitters dopamine, serotonin, noradrenaline and tyramine. Capable of transporting ATP. Mediates nucleoside export from lysosomes in macrophages, which regulates macrophage functions and numbers. |
| Protein Name | Equilibrative Nucleoside Transporter 3 Hent3 Solute Carrier Family 29 Member 3 |
| Database Links | Reactome: R-HSA-5619063 Reactome: R-HSA-83936 Reactome: R-HSA-9755088 |
| Cellular Localisation | Lysosome Membrane Multi-Pass Membrane Protein Late Endosome Membrane Mitochondrion Membrane Cell Membrane Observed In A Punctate Intracellular Pattern Showing Partial Colocalization With Late Endosomes/Lysosomes Detected At The Cell Surface Only In Certain Placental Cells |
| Alternative Antibody Names | Anti-Equilibrative Nucleoside Transporter 3 antibody Anti-Hent3 antibody Anti-Solute Carrier Family 29 Member 3 antibody Anti-SLC29A3 antibody Anti-ENT3 antibody Anti-UNQ717 antibody Anti-PRO1380 antibody |
Information sourced from Uniprot.org