Anti-SLC4A5 antibody (1042-1121) (STJ112467)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC4A5 (1042-1121) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC4A5 |
| Gene ID | 57835 |
| Uniprot ID | S4A5_HUMAN |
| Immunogen Region | 1042-1121 |
| Immunogen Sequence | DFIFSQHDLAWIDNILPEKE KKETDKKRKRKKGAHEDCDE EPQFPPPSVIKIPMESVQSD PQNGIHCIARKRSSSWSYSL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1042-1121 of human SLC4A5 (NP_597812.1). |
Additional Info
| Tissue Specificity | Highest expression observed in liver, spleen and testis.moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle. Isoform 3: Expressed in the brain, heart, kidney, testis, pancreas, muscle and peripheral blood leukocytes. |
| Function | Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. |
| Protein Name | Electrogenic Sodium Bicarbonate Cotransporter 4Nbce2Solute Carrier Family 4 Member 5 |
| Database Links | Reactome: R-HSA-425381 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneExpressed In The Apical Plasma Membrane Domain Of A Subset Of Collecting Ducts In The Renal Medulla |
| Alternative Antibody Names | Anti-Electrogenic Sodium Bicarbonate Cotransporter 4 antibodyAnti-Nbce2 antibodyAnti-Solute Carrier Family 4 Member 5 antibodyAnti-SLC4A5 antibodyAnti-NBC4 antibody |
Information sourced from Uniprot.org