Anti-SNRPB antibody (1-100) (STJ116166)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SNRPB (1-100) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SNRPB |
| Gene ID | 6628 |
| Uniprot ID | RSMB_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MTVGKSSKMLQHIDYRMRCI LQDGRIFIGTFKAFDKHMNL ILCDCDEFRKIKPKNSKQAE REEKRVLGLVLLRGENLVSM TVEGPPPKDTGIARVPLAGA |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SNRPB (NP_003082.1). |
Additional Info
| Post Translational Modifications | Methylated by PRMT5. Arg-108 and Arg-112 are dimethylated, probably to asymmetric dimethylarginine. |
| Function | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. |
| Protein Name | Small Nuclear Ribonucleoprotein-Associated Proteins B And B'Snrnp-BSm Protein B/B'Sm-B/B'Smb/B' |
| Database Links | Reactome: R-HSA-111367Reactome: R-HSA-191859Reactome: R-HSA-72163Reactome: R-HSA-72165Reactome: R-HSA-73856Reactome: R-HSA-77588Reactome: R-HSA-9754678 |
| Cellular Localisation | CytoplasmCytosolNucleusSmn-Mediated Assembly Into Core Snrnps Occurs In The Cytosol Before Smn-Mediated Transport To The Nucleus To Be Included In Spliceosomes |
| Alternative Antibody Names | Anti-Small Nuclear Ribonucleoprotein-Associated Proteins B And B' antibodyAnti-Snrnp-B antibodyAnti-Sm Protein B/B' antibodyAnti-Sm-B/B' antibodyAnti-Smb/B' antibodyAnti-SNRPB antibodyAnti-COD antibodyAnti-SNRPB1 antibody |
Information sourced from Uniprot.org