| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Small nuclear ribonucleoprotein E is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SNRPE |
| Gene ID: | 6635 |
| Uniprot ID: | RUXE_HUMAN |
| Specificity: | This antibody detects endogenous levels of SNRPE at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human SNRPE |
| Function | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing. |
| Protein Name | Small Nuclear Ribonucleoprotein E Snrnp-E Sm Protein E Sm-E Sme |
| Database Links | Reactome: R-HSA-111367 Reactome: R-HSA-191859 Reactome: R-HSA-72163 Reactome: R-HSA-72165 Reactome: R-HSA-73856 Reactome: R-HSA-77588 Reactome: R-HSA-9754678 |
| Cellular Localisation | Cytoplasm Cytosol Nucleus Smn-Mediated Assembly Into Core Snrnps Occurs In The Cytosol Before Smn-Mediated Transport To The Nucleus To Be Included In Spliceosomes |
| Alternative Antibody Names | Anti-Small Nuclear Ribonucleoprotein E antibody Anti-Snrnp-E antibody Anti-Sm Protein E antibody Anti-Sm-E antibody Anti-Sme antibody Anti-SNRPE antibody |
Information sourced from Uniprot.org