Anti-SOX6 Antibody

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Product name Anti-SOX6 Antibody
Short Description Rabbit polyclonal against SOX6
Description This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Transcription factor SOX-6
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-74 of human SOX6 (NP_001139291.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 55553
Gene Symbol SOX6
Molecular Weight 91.921 kDa
Database Links HGNC:16421
OMIM:607257
Reactome:R-HSA-3769402
Alternative Names Transcription factor SOX-6
Function Transcriptional activator, Binds specifically to the DNA sequence 5'-AACAAT-3', Plays a key role in several developmental processes, including neurogenesis and skeleton formation
Post-translational Modifications Sumoylation inhibits the transcriptional activity,
Cellular Localization Nucleus
Tissue Specificity Expressed in a wide variety of tissues, most abundantly in skeletal muscle
Swiss-Prot Key P35712
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