Anti-SSNA1 antibody (1-119) (STJ115339)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SSNA1 (1-119) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SSNA1 |
| Gene ID | 8636 |
| Uniprot ID | SSNA1_HUMAN |
| Immunogen Region | 1-119 |
| Immunogen Sequence | MTQQGAALQNYNNELVKCIE ELCQKREELCRQIQEEEDEK QRLQNEVRQLTEKLARVNEN LARKIASRNEFDRTIAETEA AYLKILESSQTLLSVLKREA GNLTKATAPDQKSSGGRDS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-119 of human SSNA1 (NP_003722.2). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | Microtubule-binding protein which stabilizes dynamic microtubules by slowing growth and shrinkage at both plus and minus ends and serves as a sensor of microtubule damage, protecting microtubules from the microtubule-severing enzyme SPAST. Induces microtubule branching which is mediated by the formation of long SSNA1 fibrils which guide microtubule protofilaments to split apart from the mother microtubule and form daughter microtubules. Plays a role in axon outgrowth and branching. Required for cell division. |
| Protein Name | Microtubule Nucleation Factor Ssna1Nuclear Autoantigen Of 14 KdaSjoegren Syndrome Nuclear Autoantigen 1 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleMidbodyFlagellum Basal BodyFlagellum AxonemeCell ProjectionAxonIn SpermStrongly Expressed In The Basal Body Region With Weaker Expression In The AxonemeLocalizes To Axon Branching Points In Neurons |
| Alternative Antibody Names | Anti-Microtubule Nucleation Factor Ssna1 antibodyAnti-Nuclear Autoantigen Of 14 Kda antibodyAnti-Sjoegren Syndrome Nuclear Autoantigen 1 antibodyAnti-SSNA1 antibodyAnti-NA14 antibody |
Information sourced from Uniprot.org