| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Symplekin is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SYMPK |
| Gene ID: | 8189 |
| Uniprot ID: | SYMPK_HUMAN |
| Specificity: | This antibody detects endogenous levels of Symplekin at Human |
| Immunogen: | Synthesized peptide derived from human Symplekin |
| Function | Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity. |
| Protein Name | Symplekin |
| Database Links | Reactome: R-HSA-159231 Reactome: R-HSA-72187 Reactome: R-HSA-72203 Reactome: R-HSA-73856 Reactome: R-HSA-77595 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Junction Tight Junction Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Nucleus Nucleoplasm Cytoplasmic Face Of Adhesion Plaques (Major) And Nucleoplasm (Minor) (In Cells With Tj) Nucleoplasm (In Cells Without Tj) Nuclear Bodies Of Heat-Stressed Cells Colocalizes With Hsf1 In Nuclear Stress Bodies Upon Heat Shock |
| Alternative Antibody Names | Anti-Symplekin antibody Anti-SYMPK antibody Anti-SPK antibody |
Information sourced from Uniprot.org