Anti-Synaptobrevin/VAMP antibody [SP10] (STJA0003787)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgM
ImmunogenSynaptic immunoprecipitate (crude) from human brain.
General Information
| Short Description | Mouse monoclonal anti-Synaptobrevin/VAMP for use in WB and IHC in Bovine, Human, Mouse, Pig, Rat, Rabbit and Hamster samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Mouse |
| Reactivity | Bovine/Human/Mouse/Pig/Rat/Rabbit/Hamster |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SP10 |
| Isotype | IgM |
| Conjugation | Unconjugated |
| Purification | This antibody was igm purified culture from supernatant. |
| Dilution Range | WB 1:1000IHC 1:100 |
| Formulation | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VAMP1 |
| Gene ID | 6843 |
| Uniprot ID | VAMP1_HUMAN |
| Immunogen | Synaptic immunoprecipitate (crude) from human brain. |
Additional Info
| Tissue Specificity | Nervous system, skeletal muscle and adipose tissue. |
| Post Translational Modifications | (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which probably hydrolyzes the 78-Gln-|-Phe-79 bond and inhibits neurotransmitter release. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which probably hydrolyzes the 61-Arg-|-Leu-62 bond and inhibits neurotransmitter release. BoNT/D has low catalytic activity on this protein due to its sequence. Note that humans are not known to be infected by C.botulinum type D. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which probably hydrolyzes the 60-Gln-|-Lys-61 bond and inhibits neurotransmitter release. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which probably hydrolyzes the 68-Arg-|-Ala-69 bond and inhibits neurotransmitter release. It remains unknown whether BoNT/X is ever produced, or what organisms it targets. |
| Function | Involved in the targeting and/or fusion of transport vesicles to their target membrane. |
| Protein Name | Vesicle-Associated Membrane Protein 1Vamp-1Synaptobrevin-1 |
| Database Links | Reactome: R-HSA-5250955Reactome: R-HSA-5250981Reactome: R-HSA-5250989 |
| Cellular Localisation | Isoform 1: Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneSingle-Pass Type Iv Membrane ProteinSynapseSynaptosomeIsoform 2: Cytoplasmic Vesicle MembraneIsoform 3: Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Vesicle-Associated Membrane Protein 1 antibodyAnti-Vamp-1 antibodyAnti-Synaptobrevin-1 antibodyAnti-VAMP1 antibodyAnti-SYB1 antibody |
Information sourced from Uniprot.org