Anti-Syntaxin 4 antibody (50-150) [S4MR] (STJ11103604)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Syntaxin 4 (50-150) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STX4 |
| Gene ID | 6810 |
| Uniprot ID | STX4_HUMAN |
| Immunogen Region | 50-150 |
| Immunogen Sequence | QTIVKLGNKVQELEKQQVTI LATPLPEESMKQELQNLRDE IKQLGREIRLQLKAIEPQKE EADENYNSVNTRMRKTQHGV LSQQFVELINKCNSMQSEYR E |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Syntaxin 4 (NP_004595.2) ). |
Additional Info
| Tissue Specificity | Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation. |
| Function | Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. Required for normal hearing. |
| Protein Name | Syntaxin-4Renal Carcinoma Antigen Ny-Ren-31 |
| Database Links | Reactome: R-HSA-114516Reactome: R-HSA-1236974Reactome: R-HSA-1445148Reactome: R-HSA-199992Reactome: R-HSA-449836 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iv Membrane ProteinCell ProjectionNeuron ProjectionStereociliumLocalizes To Neurite Tips In Neuronal Cells |
| Alternative Antibody Names | Anti-Syntaxin-4 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-31 antibodyAnti-STX4 antibodyAnti-STX4A antibody |
Information sourced from Uniprot.org