Anti-SYT11 antibody (37-200) (STJ110497)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SYT11 (37-200) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SYT11 |
| Gene ID | 23208 |
| Uniprot ID | SYT11_HUMAN |
| Immunogen Region | 37-200 |
| Immunogen Sequence | WSCCHQQAEKKQKNPPYKFI HMLKGISIYPETLSNKKKII KVRRDKDGPGREGGRRNLLV DAAEAGLLSRDKDPRGPSSG SCIDQLPIKMDYGEELRSPI TSLTPGESKTTSPSSPEEDV MLGSLTFSVDYNFPKKALVV TIQEAHGLPVMDDQTQGSDP YIKM |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 37-200 of human SYT11 (NP_689493.3). |
Additional Info
| Post Translational Modifications | Ubiquitinated, at least by PRKN, and targeted to the proteasome complex for degradation. Ubiquitination is inhibited by ATP13A2. |
| Function | Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane. Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway. |
| Protein Name | Synaptotagmin-11Synaptotagmin XiSytxi |
| Database Links | Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneSingle-Pass Membrane ProteinPerikaryonGolgi ApparatusTrans-Golgi Network MembraneRecycling Endosome MembraneLysosome MembraneCytoplasmic VesiclePhagosomeCell ProjectionAxonDendritePostsynaptic DensityClathrin-Coated Vesicle MembraneLocalized In Vesicles That Travels In Axonal And Dendritic Shafts In Both Anterograde And Retrograde DirectionsIn Macrophages And MicrogliaRecruited In Phagosomes At Early Stages Of PhagocytosisFound In The Core Of The Lewy Bodies In The Brain Of Sporadic Parkinson Disease Patients |
| Alternative Antibody Names | Anti-Synaptotagmin-11 antibodyAnti-Synaptotagmin Xi antibodyAnti-Sytxi antibodyAnti-SYT11 antibodyAnti-KIAA0080 antibody |
Information sourced from Uniprot.org