Anti-Talin-1 antibody

[STJ97271] Download PDF Print Data Sheet
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Product name Anti-Talin-1 antibody
Short Description Rabbit polyclonal to Talin-1.
Description Talin-1 is a protein encoded by the TLN1 gene which is approximately 269,2 kDa. Talin-1 is localised to the cytoplasm and cell surface. It is involved in RET signalling, integrin alphaIIb beta3 signalling, response to elevated platelet cytosolic Ca2+ and focal adhesion. It plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It co-distributes with integrins in the cell surface membrane in order to assist in the attachment of lymphocytes to other cells and attachment of adherent cells to extracellular matrices. Talin-1 is expressed in the blood, nervous system, liver, intestine and skin. Mutations in the TLN1 gene result in ovarian serous carcinoma. STJ97271 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Talin-1 protein.
Applications ELISA, IF, IHC, WB
Dilution range WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:10000
Specificity Talin-1 Polyclonal Antibody detects endogenous levels of Talin-1 protein.
Protein Name Talin-1
Immunogen Synthesized peptide derived from human Talin-1.
Immunogen Region C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application IHC WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 7094
Gene Symbol TLN1
Database Links HGNC:11845
OMIM:186745
Alternative Names Talin-1
Talin-1 antibody
KIAA1027 antibody
TLN antibody
Function Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts .
Cellular Localization Cell projection, ruffle membrane Cytoplasm, cytoskeleton Cell surface Cell junction, focal adhesion. Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions .
Swiss-Prot Key Q9Y490_HUMAN
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