| Tissue Specificity | Expressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain. |
| Function | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. |
| Protein Name | Transcription Factor 4Tcf-4Class B Basic Helix-Loop-Helix Protein 19Bhlhb19Immunoglobulin Transcription Factor 2Itf-2Sl3-3 Enhancer Factor 2Sef-2 |
| Database Links | Reactome: R-HSA-525793Reactome: R-HSA-9839394 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor 4 antibodyAnti-Tcf-4 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 19 antibodyAnti-Bhlhb19 antibodyAnti-Immunoglobulin Transcription Factor 2 antibodyAnti-Itf-2 antibodyAnti-Sl3-3 Enhancer Factor 2 antibodyAnti-Sef-2 antibodyAnti-TCF4 antibodyAnti-BHLHB19 antibodyAnti-ITF2 antibodyAnti-SEF2 antibody |
Information sourced from Uniprot.org
