| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-THEMIS2 (1-260) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
THEMIS2 |
| Gene ID: |
9473 |
| Uniprot ID: |
THMS2_HUMAN |
| Immunogen Region: |
1-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human THEMIS2 (NP_004839.2). |
| Immunogen Sequence: |
MEPVPLQDFVRALDPASLPR VLRVCSGVYFEGSIYEISGN ECCLSTGDLIKVTQVRLQKV VCENPKTSQTMELAPNFQGY FTPLNTPQSYETLEELVSAT TQSSKQLPTCFMSTHRIVTE GRVVTEDQLLMLEAVVMHLG IRSARCVLGMEGQQVILHLP LSQKGPFWTWEPSAPRTLLQ VLQDPALKDLVLTCPTLPWH SLILRPQYEIQAIMHIFSSL RIAATRSAAQTQGEDLARV |
| Tissue Specificity | Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1. |
| Post Translational Modifications | Phosphorylation at Tyr-632 is induced by LPS. Phosphorylated by Src kinases (Lck or Fyn) following BCR engagement. |
| Function | May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways. |
| Protein Name | Protein Themis2Induced By Contact To Basement Membrane 1 ProteinProtein Icb-1Thymocyte-Expressed Molecule Involved In Selection Protein 2 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Protein Themis2 antibodyAnti-Induced By Contact To Basement Membrane 1 Protein antibodyAnti-Protein Icb-1 antibodyAnti-Thymocyte-Expressed Molecule Involved In Selection Protein 2 antibodyAnti-THEMIS2 antibodyAnti-C1orf38 antibodyAnti-ICB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
