Anti-TMX1 antibody (210-280) (STJ117135)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TMX1 (210-280) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMX1 |
| Gene ID | 81542 |
| Uniprot ID | TMX1_HUMAN |
| Immunogen Region | 210-280 |
| Immunogen Sequence | KRRRPQPYPYPSKKLLSESA QPLKKVEEEQEADEEDVSEE EAESKEGTNKDFPQNAIRQR SLGPSLATDKS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 210-280 of human TMX1 (NP_110382.3). |
Additional Info
| Tissue Specificity | Ubiquitous. Highly expressed in kidney, liver, placenta and lung. |
| Post Translational Modifications | Palmitoylated.palmitoylation is required for localization to mitochondria-associated endoplasmic reticulum membrane (MAM). |
| Function | Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol. The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids. Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds. Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane. Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane. Acts as a negative regulator of platelet aggregation following secretion in the extracellular space. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals. Regulates endoplasmic reticulum-mitochondria Ca(2+) flux. |
| Protein Name | Thioredoxin-Related Transmembrane Protein 1Protein Disulfide-Isomerase Tmx1Thioredoxin Domain-Containing Protein 1Transmembrane Trx-Related Protein |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinMitochondrion MembraneSecretedPredominantly Found In The Endoplasmic ReticulumSecreted In The Extracellular Space Following Thrombin StimulationLocalizes To Mitochondria-Associated Endoplasmic Reticulum Membrane (Mam)Palmitoylation Is Required For Mam Localization |
| Alternative Antibody Names | Anti-Thioredoxin-Related Transmembrane Protein 1 antibodyAnti-Protein Disulfide-Isomerase Tmx1 antibodyAnti-Thioredoxin Domain-Containing Protein 1 antibodyAnti-Transmembrane Trx-Related Protein antibodyAnti-TMX1 antibodyAnti-TMX antibodyAnti-TXNDC antibodyAnti-TXNDC1 antibodyAnti-PSEC0085 antibodyAnti-UNQ235 antibodyAnti-PRO268 antibody |
Information sourced from Uniprot.org