| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Transthyretin (81-130) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-p 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TTR |
| Gene ID: | 7276 |
| Uniprot ID: | TTHY_HUMAN |
| Immunogen Region: | 81-130 |
| Specificity: | This antibody detects endogenous levels of Human Prealbumin |
| Immunogen: | Synthesized peptide derived from human Prealbumin AA range: 81-130 |
| Tissue Specificity | Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver. |
| Post Translational Modifications | Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYLD1 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway. Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation. |
| Function | Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. |
| Protein Name | Transthyretin Attr Prealbumin Tbpa |
| Database Links | Reactome: R-HSA-2453864 Reactome: R-HSA-2453902 Reactome: R-HSA-3000171 Reactome: R-HSA-6798695 Reactome: R-HSA-975634 Reactome: R-HSA-977225 |
| Cellular Localisation | Secreted Cytoplasm |
| Alternative Antibody Names | Anti-Transthyretin antibody Anti-Attr antibody Anti-Prealbumin antibody Anti-Tbpa antibody Anti-TTR antibody Anti-PALB antibody |
Information sourced from Uniprot.org