Anti-VDAC3 antibody (1-283) (STJ112562)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal VDAC3 (1-283) antibody for use in WB, IHC-P, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VDAC3 |
| Gene ID | 7419 |
| Uniprot ID | VDAC3_HUMAN |
| Immunogen Region | 1-283 |
| Immunogen Sequence | MCNTPTYCDLGKAAKDVFNK GYGFGMVKIDLKTKSCSGVE FSTSGHAYTDTGKASGNLET KYKVCNYGLTFTQKWNTDNT LGTEISWENKLAEGLKLTLD TIFVPNTGKKSGKLKASYKR DCFSVGSNVDIDFSGPTIYG WAVLAFEGWLAGYQMSFDTA KSKLSQNNFALGYKAADFQL HTHVNDGTEFGGSIYQKVNE KIETSINLAWTAGSNNTRFG IAAKYMLDCRTSLSAKVNN |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-283 of human VDAC3 (NP_005653.3). |
Additional Info
| Tissue Specificity | Expressed in erythrocytes (at protein level). Widely expressed. Highest in testis. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations. Involved in male fertility and sperm mitochondrial sheath formation. |
| Protein Name | Non-Selective Voltage-Gated Ion Channel Vdac3Vdac-3Hvdac3Outer Mitochondrial Membrane Protein Porin 3 |
| Database Links | Reactome: R-HSA-5205685Reactome: R-HSA-5689880Reactome: R-HSA-8949215 |
| Cellular Localisation | Mitochondrion Outer MembraneMembraneMay Localize To Non-Mitochondrial Membranes |
| Alternative Antibody Names | Anti-Non-Selective Voltage-Gated Ion Channel Vdac3 antibodyAnti-Vdac-3 antibodyAnti-Hvdac3 antibodyAnti-Outer Mitochondrial Membrane Protein Porin 3 antibodyAnti-VDAC3 antibody |
Information sourced from Uniprot.org