Anti-Vitronectin antibody [BV1] (STJ16100270)

SKU:
STJ16100270-1

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Host: Mouse
Applications: FC/ELISA/IF/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Vitronectin is suitable for use in Flow Cytometry, ELISA, Immunofluorescence, Immunoprecipitation and Western Blot research applications.
Clonality: Monoclonal
Clone ID: BV1
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS with 0.1% BSA and 0.02% sodium azide
Concentration: 100 ug/mL
Dilution Range: FC 1:50
IP 1:50
ELISA 1:50
WB 1:50
IP 1:50
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: VTN
Gene ID: 7448
Uniprot ID: VTNC_HUMAN
Tissue Specificity Expressed in the retina pigment epithelium (at protein level). Expressed in plasma (at protein level). Expressed in serum (at protein level).
Post Translational Modifications Sulfated on tyrosine residues. N- and O-glycosylated. Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading. It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both. Phosphorylation sites are present in the extracellular medium.
Function Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
Protein Name Vitronectin
Vn
S-Protein
Serum-Spreading Factor
V75 Cleaved Into - Vitronectin V65 Subunit - Vitronectin V10 Subunit - Somatomedin-B
Database Links Reactome: R-HSA-2129379
Reactome: R-HSA-216083
Reactome: R-HSA-3000170
Reactome: R-HSA-3000178
Reactome: R-HSA-977606
Cellular Localisation Secreted
Extracellular Space
Parasitophorous Vacuole
(Microbial Infection) In P
Falciparum-Infected Red Blood Cells
Vtn Internalization Is Detected At The Early Trophozoite Stage
Colocalizes With Sera5 At The Schizont Stage And With Sera5 P47 At The Merozoite Surface
Alternative Antibody Names Anti-Vitronectin antibody
Anti-Vn antibody
Anti-S-Protein antibody
Anti-Serum-Spreading Factor antibody
Anti-V75 Cleaved Into - Vitronectin V65 Subunit - Vitronectin V10 Subunit - Somatomedin-B antibody
Anti-VTN antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance