Anti-WWC2 antibody (160-430) (STJ11101466)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal WWC2 (160-430) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | WWC2 |
| Gene ID | 80014 |
| Uniprot ID | WWC2_HUMAN |
| Immunogen Region | 160-430 |
| Immunogen Sequence | DPDILKAEISTTRLRVKKLK RELSQMKQELLYKEQGFETL QQIDKKMSGGQSGYELSEAK AILTELKSIRKAISSGEKEK QDLMQSLAKLQERFHLDQNI GRSEPDLRCSPVNSHLCLSR QTLDAGSQTSISGDIGVRSR SNLAEKVRLSLQYEEAKRSM ANLKIELSKLDSEAWPGALD IEKEKLMLINEKEELLKELQ FVTPQKRTQDELERLEAERQ RLEEELLSVRGTPSRALAE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 160-430 of human WWC2 (NP_079225.5). |
Additional Info
| Function | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. |
| Protein Name | Protein Wwc2Bh-3-Only Member BWw Domain-Containing Protein 2 |
| Database Links | |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Protein Wwc2 antibodyAnti-Bh-3-Only Member B antibodyAnti-Ww Domain-Containing Protein 2 antibodyAnti-WWC2 antibodyAnti-BOMB antibody |
Information sourced from Uniprot.org