| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | XPO4 |
| Gene ID: | 64328 |
| Uniprot ID: | XPO4_HUMAN |
| Immunogen Region: | 400-700 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human XPO4 (NP_071904.4). |
| Immunogen Sequence: | MEAYDKLLESWLTLVQDDKH FHKGFFTQHAVQVFNSYIQC HLAAPDGTRNLTANGVASRE EEEISELQEDDRDQFSDQLA SVGMLGRIAAEHCIPLLTSL LEERVTRLHGQLQRHQQQLL ASPGSSTVDNKMLDDLYEDI HWLILVTGYLLADDTQGETP LIPPEIMEYSIKHSSEVDIN TTLQILGSPGEKASSIPGYN RTDSVIRLLSAILRVSEVES RAIRADLTHLLSPQMGKDI |
| Function | Mediates the nuclear export of proteins (cargos), such as EIF5A, SMAD3 and isoform M2 of PKM (PKM2). In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Catalyzes the nuclear export of hypusinated EIF5A.a small cytoplasmic protein that enters nucleus and accumulates within nucleolus if not exported back by XPO4. Specifically mediates nuclear export of isoform M2 of PKM (PKM2) following PKM2 deacetylation by SIRT6. Also mediates the nuclear import of SOX transcription factors SRY and SOX2. |
| Protein Name | Exportin-4 Exp4 |
| Cellular Localisation | Cytoplasm Nucleus Shuttles Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Exportin-4 antibody Anti-Exp4 antibody Anti-XPO4 antibody Anti-KIAA1721 antibody |
Information sourced from Uniprot.org