| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Zinc finger CCCH-type with G patch domain-containing protein (34-84) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZGPAT |
| Gene ID: | 84619 |
| Uniprot ID: | ZGPAT_HUMAN |
| Immunogen Region: | 34-84 |
| Specificity: | This antibody detects endogenous levels of human ZGPAT |
| Immunogen: | Synthesized peptide derived from human ZGPAT AA range: 34-84 |
| Post Translational Modifications | Ubiquitinated in case of infection by HIV-1, leading to its degradation. Ubiquitination is mediated by the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex that is hijacked by HIV-1 via interaction between HIV-1 Vpr and DCAF1/VPRBP. |
| Function | Transcription repressor that specifically binds the 5'-GGAGGAAGAA-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA. |
| Protein Name | Zinc Finger Ccch-Type With G Patch Domain-Containing Protein G Patch Domain-Containing Protein 6 Zinc Finger Ccch Domain-Containing Protein 9 Zinc Finger And G Patch Domain-Containing Protein |
| Cellular Localisation | Nucleus Isoform 4: Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Ccch-Type With G Patch Domain-Containing Protein antibody Anti-G Patch Domain-Containing Protein 6 antibody Anti-Zinc Finger Ccch Domain-Containing Protein 9 antibody Anti-Zinc Finger And G Patch Domain-Containing Protein antibody Anti-ZGPAT antibody Anti-GPATC6 antibody Anti-GPATCH6 antibody Anti-KIAA1847 antibody Anti-ZC3H9 antibody Anti-ZC3HDC9 antibody Anti-ZIP antibody |
Information sourced from Uniprot.org