| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-DNA annealing helicase and endonuclease ZRANB3 is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ZRANB3 |
| Gene ID: | 84083 |
| Uniprot ID: | ZRAB3_HUMAN |
| Specificity: | This antibody detects endogenous levels of ZRANB3 at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human ZRANB3 |
| Function | DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks. |
| Protein Name | Dna Annealing Helicase And Endonuclease Zranb3 Annealing Helicase 2 Ah2 Zinc Finger Ran-Binding Domain-Containing Protein 3 Includes - Dna Annealing Helicase Zranb3 - Endonuclease Zranb3 |
| Cellular Localisation | Nucleus Chromosome Following Dna Damage Recruited To Sites Of Dna Damage And Stalled Replication Forks By Polyubiquitinated Pcna |
| Alternative Antibody Names | Anti-Dna Annealing Helicase And Endonuclease Zranb3 antibody Anti-Annealing Helicase 2 antibody Anti-Ah2 antibody Anti-Zinc Finger Ran-Binding Domain-Containing Protein 3 Includes - Dna Annealing Helicase Zranb3 - Endonuclease Zranb3 antibody Anti-ZRANB3 antibody |
Information sourced from Uniprot.org