| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.113ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This SYTL2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
SYTL2 |
| Gene ID: |
54843 |
| Uniprot ID: |
SYTL2_HUMAN |
| Sample Type: |
tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells. |
| Post Translational Modifications | Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A. |
| Function | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. |
| Protein Name | Synaptotagmin-Like Protein 2Breast Cancer-Associated Antigen Sga-72mExophilin-4 |
| Database Links | |
| Cellular Localisation | Isoform 1: CytoplasmCell MembraneRecruited On Vesicular Structures In Cytotoxic T-Lymphocytes (Ctl) By Rab27aIsoform 4: Cell MembraneIn The Pancreatic Alpha Cells Distributed In Both Peripheral And Anterior RegionsLocalizes On The Glucagon Granules In The Cell Periphery |
| Alternative ELISA Names | Synaptotagmin-Like Protein 2 ELISA kitBreast Cancer-Associated Antigen Sga-72m ELISA kitExophilin-4 ELISA kitSYTL2 ELISA kitKIAA1597 ELISA kitSGA72M ELISA kitSLP2 ELISA kitSLP2A ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
