• Rat CRHR1 (Corticotropin Releasing Hormone Receptor 1) Sandwich ELISA Kit (STJE0008143)

Rat CRHR1 (Corticotropin Releasing Hormone Receptor 1) Sandwich ELISA Kit (STJE0008143)

SKU:
STJE0008143

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.123ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This CRHR1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Crhr1
Gene ID: 58959
Uniprot ID: CRFR1_RAT
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Detected in brain, especially in cerebellum. Detected in pituitary gland, and at lower levels in the olfactory bulb.
Post Translational Modifications C-terminal Ser or Thr residues may be phosphorylated. Phosphorylation at Ser-301 by PKA prevents maximal coupling to Gq-protein, and thereby negatively regulates downstream signaling.
Function G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
Protein Name Corticotropin-Releasing Factor Receptor 1
Crf-R-1
Crf-R1
Crfr-1
Corticotropin-Releasing Hormone Receptor 1
Crh-R-1
Crh-R1
Database Links Reactome: R-RNO-373080
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endosome
Agonist-Binding Promotes Endocytosis
Alternative ELISA Names Corticotropin-Releasing Factor Receptor 1 ELISA kit
Crf-R-1 ELISA kit
Crf-R1 ELISA kit
Crfr-1 ELISA kit
Corticotropin-Releasing Hormone Receptor 1 ELISA kit
Crh-R-1 ELISA kit
Crh-R1 ELISA kit
Crhr1 ELISA kit
Crhr ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance