• Rat GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B) Sandwich ELISA Kit (STJE0009307)

Rat GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B) Sandwich ELISA Kit (STJE0009307)

SKU:
STJE0009307

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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.133ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This GRIN2B Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Grin2b
Gene ID: 24410
Uniprot ID: NMDE2_RAT
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in the hippocampus including the dentate gyrus (at protein level). Detected in adult olfactory bulb, brain cortex, hippocampus, striatum, thalamus, superior colliculus, with much lower levels in inferior colliculus, midbrain and cerebellum.
Post Translational Modifications Phosphorylated on tyrosine residues. Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity.
Function Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity.
Protein Name Glutamate Receptor Ionotropic - Nmda 2b
Glun2b
Glutamate Nmda Receptor Subunit Epsilon-2
N-Methyl D-Aspartate Receptor Subtype 2b
Nmdar2b
Nr2b
Database Links Reactome: R-RNO-3928662
Reactome: -RNO-438066
Reactome: -RNO-5673001
Reactome: -RNO-8849932
Reactome: -RNO-9609736
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Late Endosome
Lysosome
Cytoplasm
Cytoskeleton
Co-Localizes With The Motor Protein Kif17 Along Microtubules
Alternative ELISA Names Glutamate Receptor Ionotropic - Nmda 2b ELISA kit
Glun2b ELISA kit
Glutamate Nmda Receptor Subunit Epsilon-2 ELISA kit
N-Methyl D-Aspartate Receptor Subtype 2b ELISA kit
Nmdar2b ELISA kit
Nr2b ELISA kit
Grin2b ELISA kit
output

Information sourced from Uniprot.org

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