Anti-GREM2 antibody

[STJ116503] Download PDF Print Data Sheet

* Required Fields

Product name Anti-GREM2 antibody
Short Description Rabbit polyclonal against GREM2
Description This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Gremlin-2
Cysteine Knot Superfamily 1 - Bmp Antagonist 2
Dan Domain Family Member 3
Protein Related To Dan And Cerberus
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human GREM2 (NP_071914. 3).
Storage Instruction Store at -20°C and avoid freeze-thaw cycles.
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Gene ID 64388
Gene Symbol GREM2
Molecular Weight Calculated: 19kDa. Observed: 19kDa
Database Links Reactome: R-HSA-201451
Alternative Names Anti-Gremlin-2 antibody
Anti-Cysteine Knot Superfamily 1 - Bmp Antagonist 2 antibody
Anti-Dan Domain Family Member 3 antibody
Anti-Protein Related To Dan And Cerberus antibody
Anti-GREM2 CKTSF1B2 DAND3 PRDC antibody
Function Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.
Post-translational Modifications N-glycosylated.
Cellular Localization Secreted
Swiss-Prot Key GREM2_HUMAN
Bad Good
Enter the code in the box below:

Ask us a question

No questions yet. Be the first to ask the question!


Use spaces to separate tags. Use single quotes (') for phrases.