Anti-GREM2 Antibody

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Product name Anti-GREM2 Antibody
Short Description Rabbit polyclonal against GREM2
Description This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Gremlin-2
Cysteine knot superfamily 1
BMP antagonist 2
DAN domain family member 3
Protein related to DAN and cerberus
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human GREM2 (NP_071914.3).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 64388
Gene Symbol GREM2
Molecular Weight 19.32 kDa
Database Links HGNC:17655
OMIM:608832
Reactome:R-HSA-201451
Alternative Names Gremlin-2
Cysteine knot superfamily 1
BMP antagonist 2
DAN domain family member 3
Protein related to DAN and cerberus
Function Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members, Contributes to the regulation of embryonic morphogenesis via BMP family members, Antagonizes BMP4-induced suppression of progesterone production in granulosa cells,
Post-translational Modifications N-glycosylated,
Cellular Localization Secreted
Swiss-Prot Key Q9H772
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