• Western blot analysis of A549, using IL17C rabbit polyclonal antibody (STJ112601) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
  • Immunofluorescence analysis of H9C2 cells using IL17C rabbit polyclonal antibody (STJ112601) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of L929 cells using IL17C rabbit polyclonal antibody (STJ112601) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of U2OS cells using IL17C rabbit polyclonal antibody (STJ112601) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Anti-IL17C antibody (19-197) (STJ112601)

SKU:
STJ112601

£169.50 - £449.50
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Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-IL17C (19-197) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IL17C
Gene ID: 27189
Uniprot ID: IL17C_HUMAN
Immunogen Region: 19-197
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 19-197 of human IL17C (NP_037410.1).
Immunogen Sequence: HHDPSLRGHPHSHGTPHCYS AEELPLGQAPPHLLARGAKW GQALPVALVSSLEAASHRGR HERPSATTQCPVLRPEEVLE ADTHQRSISPWRYRVDTDED RYPQKLAFAECLCRGCIDAR TGRETAALNSVRLLQSLLVL RRRPCSRDGSGLPTPGAFAF HTEFIHVPVGCTCVLPRSV
Function Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
Protein Name Interleukin-17c
Il-17c
Cytokine Cx2
Database Links Reactome: R-HSA-448424
Cellular Localisation Secreted
Alternative Antibody Names Anti-Interleukin-17c antibody
Anti-Il-17c antibody
Anti-Cytokine Cx2 antibody
Anti-IL17C antibody
Anti-UNQ561 antibody
Anti-PRO1122 antibody

Information sourced from Uniprot.org

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