| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-OPRL1 (270-370) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OPRL1 |
| Gene ID: |
4987 |
| Uniprot ID: |
OPRX_HUMAN |
| Immunogen Region: |
270-370 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 270-370 of human OPRL1 (NP_000904.1) |
| Immunogen Sequence: |
AVFVGCWTPVQVFVLAQGLG VQPSSETAVAILRFCTALGY VNSCLNPILYAFLDENFKAC FRKFCCASALRRDVQVSDRV RSIAKDVALACKTSETVPRP A |
| Tissue Specificity | Detected in blood leukocytes. |
| Post Translational Modifications | Phosphorylation at Ser-363 requires GRK3. |
| Function | G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. |
| Protein Name | Nociceptin ReceptorKappa-Type 3 Opioid ReceptorKor-3Orphanin Fq Receptor |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleLigand Binding Leads To Receptor Internalization Into Cytoplasmic VesiclesDecreasing The Amount Of Available Receptor At The Cell SurfaceInternalization Requires Phosphorylation At Ser-363Can Recycle To The Cell Membrane |
| Alternative Antibody Names | Anti-Nociceptin Receptor antibodyAnti-Kappa-Type 3 Opioid Receptor antibodyAnti-Kor-3 antibodyAnti-Orphanin Fq Receptor antibodyAnti-OPRL1 antibodyAnti-OOR antibodyAnti-ORL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
