| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-P2RX7 (47-595) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
P2RX7 |
| Gene ID: |
5027 |
| Uniprot ID: |
P2RX7_HUMAN |
| Immunogen Region: |
47-595 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 47-595 of human P2RX7 (NP_002553.3). |
| Immunogen Sequence: |
SDKLYQRKEPVISSVHTKVK GIAEVKEEIVENGVKKLVHS VFDTADYTFPLQGNSFFVMT NFLKTEGQEQRLCPEYPTRR TLCSSDRGCKKGWMDPQSKG IQTGRCVVYEGNQKTCEVSA WCPIEAVEEAPRPALLNSAE NFTVLIKNNIDFPGHNYTTR NILPGLNITCTFHKTQNPQC PIFRLGDIFRETGDNFSDVA IQGGIMGIEIYWDCNLDRWF HHCRPKYSFRRLDDKTTNV |
| Tissue Specificity | Widely expressed with highest levels in brain and immune tissues. |
| Post Translational Modifications | Phosphorylation results in its inactivation. ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel. Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface. |
| Function | Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells. |
| Protein Name | P2x Purinoceptor 7P2x7Atp ReceptorP2z ReceptorPurinergic Receptor |
| Database Links | Reactome: R-HSA-139853Reactome: R-HSA-418346Reactome: R-HSA-844456Reactome: R-HSA-9660826 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-P2x Purinoceptor 7 antibodyAnti-P2x7 antibodyAnti-Atp Receptor antibodyAnti-P2z Receptor antibodyAnti-Purinergic Receptor antibodyAnti-P2RX7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
