| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PACS1 (420-560) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:3000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PACS1 |
| Gene ID: |
55690 |
| Uniprot ID: |
PACS1_HUMAN |
| Immunogen Region: |
420-560 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 420-560 of human PACS1 (NP_060496.2). |
| Immunogen Sequence: |
SKGSLGKDTTSPMELAALEK IKSTWIKNQDDSLTETDTLE ITDQDMFGDASTSLVVPEKV KTPMKSSKTDLQGSASPSKV EGVHTPRQKRSTPLKERQLS KPLSERTNSSDSERSPDLGH STQIPRKVVYDQLNQILVSD A |
| Function | Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations. |
| Protein Name | Phosphofurin Acidic Cluster Sorting Protein 1Pacs-1 |
| Database Links | Reactome: R-HSA-164940 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkLocalizes In The Perinuclear RegionProbably The Tgn |
| Alternative Antibody Names | Anti-Phosphofurin Acidic Cluster Sorting Protein 1 antibodyAnti-Pacs-1 antibodyAnti-PACS1 antibodyAnti-KIAA1175 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
