| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TESC (135-214) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TESC |
| Gene ID: |
54997 |
| Uniprot ID: |
CHP3_HUMAN |
| Immunogen Region: |
135-214 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 135-214 of human TESC (NP_060369.3). |
| Immunogen Sequence: |
YRNVVEELLSGNPHIEKESA RSIADGAMMEAASVCMGQME PDQVYEGITFEDFLKIWQGI DIETKMHVRFLNMETMALCH |
| Tissue Specificity | Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta. |
| Function | Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. |
| Protein Name | Calcineurin B Homologous Protein 3TescalcinTsc |
| Cellular Localisation | NucleusCytoplasmMembraneLipid-AnchorCell MembraneCell ProjectionLamellipodiumRuffle MembraneColocalizes With Slc9a1 At The Plasma Membrane |
| Alternative Antibody Names | Anti-Calcineurin B Homologous Protein 3 antibodyAnti-Tescalcin antibodyAnti-Tsc antibodyAnti-TESC antibodyAnti-CHP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
